Paget’s disease of the nipple or breast is a rare type of breast cancer, which can occur in women and men. It shows up in and around the nipple, and usually signals the presence of breast cancer beneath the skin. Most cases are found in menopausal women, but can also appear in women that are as young as 20. The disease is named for Sir James Paget. He reported on the link between changes in the nipple and the underlying breast cancer.
Signs and symptoms:
Early stages: (appearance of nipple skin)
- redness
- scaly and flaky skin
- mild irritation of skin
- tingling in nipple skin
- itchiness that doesn’t respond to creams
- very sensitive skin on the nipple
- burning or painful nipple skin
- ooze or bloody discharge from the nipple (not milk)
- nipple retraction (pulls into the breast)
- scaly rash on areola skin
- breast lump beneath the affected skin
Tests to diagnose Paget's Disease of the nipple:
If any of the signs and symptoms appear and do not respond to home treatment (creams or ointments), see a health professional. The following tests can be done to pinpoint what the cause may be.
- visual examination
- biopsy and pathology of tissue sample
- analysis of nipple discharge
- mammography and/or ultrasound
- breast MRI
What may cause Paget’s disease of the nipple?
Research is still being done on the cause of Paget’s disease, but there are two leading theories.
- If invasive breast cancer or ductal carcinoma in situ (DCIS) is already present in the breast as a tumor, cells might drift off from the tumor and float up through the milk ducts, where they enter the nipple and areola.
- In a few cases of Paget’s disease, there is no underlying breast cancer, or if a tumor is present, it is unrelated to the disease in the nipple. Researchers suggest that in those cases, nipple skin cells may spontaneously change into cancer cells.
Treatments:
Each case of Paget’s disease will need treatment to match the size and stage of the cancer. The most common treatments are: Surgery
- modified radical mastectomy
- simple mastectomy
- lumpectomy
- sentinel lymph node biopsy (to determine whether or not the cancer has spread beyond the original site)
Adjuvant Treatments
- radiation (to prevent return of the cancer)
- chemotherapy (depends on the stage of the cancer)
- hormone therapy
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